PTEN Tumor Suppressor
PTEN is a tumor suppressor: The PTEN tumor suppressor gene is a dual specificity
phosphatase located on chromosome 10 (10q23) that acts through an Akt-dependent
pathway to suppress cell division ands enable apoptosis. PTEN plays
an important role in the modulation of the 1-phosphatidylinositol 3-kinase
(PtdIns 3-kinase) pathway, by catalyzing the degradation of the PtdIns(3,4,5)P3
generated by PtdIns 3-kinase; this inhibits the downstream functions mediated
by the PtdIns 3-kinase pathway, such as activation of protein kinase B
(PKB, also known as Akt), cell survival and cell proliferation. Furthermore,
PTEN modulates cell migration and invasion by negatively regulating the
signals generated at the focal adhesions, through the direct dephosphorylation
and inhibition of focal adhesion kinase (FAK). Growth factor receptor signaling
is also negatively regulated by PTEN, through the inhibition of the adaptor
protein Shc.
Provided is a recombinant PTEN, expressed in E. Coli, purified
under native condition.
PTEN/MMAC1/TEP1
95% pure,
50ug,
Cat. No. 2006018 $380.00
Reference:
Besson A, Robbins SM, Yong VW. PTEN/MMAC1/TEP1 in signal transduction
and tumorigenesis. Eur J Biochem. 1999 Aug;263(3):605-11.
Proteins are for research only, not to be used in human being. |
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