Apoptosis Proteins
Apoptosis is a major biological process.
Living or dying is controlled through a class of proteins. Some protein keep
cell living (anti-apoptosis protein, e.g. Bcl-2), other proteins initiate the
apoptosis (pro-apoptosis proteins, e.g. Bax). Interaction between your
proteins and apoptosis proteins may be an evidence that they function through
apoptosis pathway. supplies a reagent grade of common apoptosis
proteins for your convenience. These apoptosis proteins are active. The
discovery of channel function of Bcl-2 is based on our pure Bcl-2
protein. Other interesting properties of Bax are also observed through our
pure Bax protein.
Provided are recombinant proteins, expressed in E.
Coli, purified under native
condition (except Bcl-2). Proteins can be used as input marker or positive
control (Western Blotting). They are also suitable for function
study (binding assay), specifically, you may try to identify if
your proteins interact with these apoptosis proteins. For this purpose,
we present selectively one set of Bcl-2 mutants and one set of Bax
mutants as your negative controls. BID and Bax samples have no detergents,
are suitable for inducing cytochrome C release from mitochondria.
If you need other apoptosis proteins/domains, please contact us. If proteins
work for you, and you need more, we will offer bulk
rate ($1600/1000ug).
New customer, we will ship double amount of
protein!
Bcl-2:
Human, 95%,
50ug, Cat. No. 20020056, $380
Bcl-2 (-BH1): Human,
95%, 50ug, Cat. No. 20040110, $380
Bcl-2
(-BH2): Human,
95%, 50ug, Cat. No. 20040120, $380
Bcl-2
(-BH3): Human,
95%, 50ug, Cat. No. 20040130, $380
Bcl-2
(-BH4): Human,
95%, 50ug, Cat. No. 20040140, $380
Bcl-2 (-NWGR):
Human,
95%, 50ug, Cat. No. 20040150, $380
Bcl-2
N-terminal,8K Human,
95%, 50ug, Cat. No. 20040160, $380
Bcl-2 Mixture (Bcl-2,
N-terminal, and
C-terminal):
Human, 95%, 50ug, Cat. No.
20040170, $380
Bcl-XL:
Human, 95%,
50ug, Cat. No. 20020057, $380
BID:
Mouse, 95%,
50ug, Cat. No. 20020058, $380
tBID:
Mouse, 95%,
50ug, Cat. No. 20040058, $380
Bax:
Mouse, 95%,
50ug, Cat. No. 20020059, $380
GST-Bcl-XL:
Human, 95%,
100ug, Cat. No. 20020018, $380
GST-BID:
Mouse, 95%,
100ug, Cat. No. 20020019, $380
GST-Bax:
Mouse, 95%,
100ug, Cat. No. 20020020, $380
GST-Bax (-BH1): Mouse,
95%, 100ug, Cat. No. 20040010, $380
GST-Bax (-BH2): Mouse,
95%, 100ug, Cat. No. 20040020, $380
GST-Bax
(-BH3):
Mouse, 95%, 100ug, Cat. No. 20040030, $380
GST-Bax
(-IGDE):
Mouse, 95%, 100ug, Cat. No. 20040040, $380
GST-Bax D/A in
IGDE:Mouse,
95%, 100ug, Cat. No. 20040050, $380
GST:
95%, 100ug, Cat. No. 20020021, Free
Other apoptosis domains/proteins (Not in stock)
Fas cytosolic domain, Ded
domain, Card domain, F-Box domain, Dap3, SKP, Bcl-G, Bak, Bad, Bik, Ced4, Daxx, Apaf-1, Grim
Selected
References:
1. Schendel SL, Xie Z,
Montal MO, Matsuyama S, Montal M, Reed JC. Channel formation by antiapoptotic
protein Bcl-2. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5113-8.
2. Jurgensmeier JM, Xie Z,
Deveraux Q, Ellerby L, Bredesen D, Reed JC. Bax directly induces release of
cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A. 1998 Apr
28;95(9):4997-5002
3. Marzo I, Brenner C,
Zamzami N, Jurgensmeier JM, Susin SA, Vieira HL, Prevost MC, Xie Z, Matsuyama
S, Reed JC, Kroemer G. Bax and adenine nucleotide translocator cooperate in
the mitochondrial control of apoptosis. Science. 1998 Sep
25;281(5385):2027-31.
4. Li H, Kolluri SK, Gu J,
Dawson MI, Cao X, Hobbs PD, Lin B, Chen G, Lu J, Lin F, Xie Z, Fontana JA,
Reed JC, Zhang X. Cytochrome c release and apoptosis induced by mitochondrial
targeting of nuclear orphan receptor TR3. Science. 2000 Aug
18;289(5482):1159-64.
Proteins are for research only,
not to be used in human being. GST technology is licensed from Chemicom
International, Inc.
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